BackgroundObtaining informed consent for participation in genomic research in low-income settings presents specific ethical issues requiring attention. These include the challenges that arise when providing information about unfamiliar and technical research methods, the implications of complicated infrastructure and data sharing requirements, and the potential consequences of future research with samples and data. This study investigated researchers’ and participants’ parents’ experiences of a consent process and understandings of a genome-wide association study of malaria involving children aged five and under in Mali. (...) It aimed to inform best practices in recruiting participants into genomic research.MethodsA qualitative rapid ethical assessment was undertaken. Fifty-five semi-structured interviews were conducted with the parents of research participants. An additional nine semi-structured interviews were conducted with senior research scientists, research assistants and with a member of an ethics committee. A focus group with five parents of research participants and direct observations of four consent processes were also conducted. French and translated English transcripts were descriptively and thematically coded using OpenCode software.ResultsParticipants’ parents in the MalariaGEN study had differing understandings of the causes of malaria, the rationale for collecting blood samples, the purposes of the study and the kinds of information the study would generate. Genomic aspects of the research, including the gene/environment interaction underlying susceptibility or resistance to severe malaria, proved particularly challenging to explain and understand.ConclusionsThis study identifies a number of areas to be addressed in the design of consent processes for genomic research, some of which require careful ethical analysis. These include determining how much information should be provided about differing aspects of the research and how best to promote understandings of genomic research. We conclude that it is important to build capacity in the design and conduct of effective and appropriate consent processes for genomic research in low and middle-income settings. Additionally, consideration should be given to the role of review committees and community consultation activities in protecting the interests of participants in genomic research. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Abhidhamma Studies: Buddhist Explorations of Consciousness and TimeDouglas W. ShraderAbhidhamma Studies: Buddhist Explorations of Consciousness and Time. By Venerable Nyanaponika Thera. Fourth edition. Edited with an introduction by Bhikkhu Bodhi. Boston: Wisdom Publications, 1998. Pp. 160. Paper $16.95.The delightful, thought-provoking Abhidhamma Studies: Buddhist Explorations of Consciousness and Timeby the Venerable Nyanaponika Thera is the fourth incarnation of a text originally composed shortly after World (...) War II, published in 1949 (Frewin and Co., Ltd.). The Buddhist Publication Society issued a second, revised and enlarged edition in 1965 as well as a third edition, with relatively minor corrections, in 1976. The present edition, edited by Bhikkhu Bodhi, incorporates a variety of welcome changes, reflecting considerable effort and devotion to the task. In addition to authoring a superb introductory essay, Bodhi has "reformulated a few awkward sentences..., reorganized the notes, provided additional references, and supplied a bibliography" (p. viii). Perhaps the most intriguing and potentially significant change is evident in the title itself. Originally subtitled Researches in Buddhist Psychology, an apt but relatively uninformative description of its contents, the title now announces, even to the uninitiated, the book's unique, captivating subject matter: Buddhist Explorations of Consciousness and Time.This book is essential reading for any serious student of Buddhism. Additionally, it will appeal to those interested in a wide variety of both phenomenological and ontological issues: the manifold of experience, the nature of consciousness, the analysis of time, concepts of anattā(ego selflessness) and paticca-samuppāda(dependent origination), and so forth. An intermediate to advanced level of familiarity and understanding of basic Buddhist doctrines is recommended. It will prove particularly useful to scholars and students who have been intimidated by the vast, often cryptic, Abhidhamma literature.Apparently, the Buddha and his teachings were as enticing and yet profoundly puzzling and enigmatic to his contemporaries and followers as they remain to millions today. They challenge everything we commonly take to be real. That which appears substantial, we are told, is not. Contrary to our own (unexamined) inner/ subjective experience, as well as the teachings of most major world religions, we neither arenor havea self, for there is no self either to be or to have. The attempt to reconcile the teachings of the Buddha with existing beliefs and assumptions concerning the nature of reality led to a proliferation of competing philosophical schools. Each school developed its own distinctive Abhidhamma literature, ostensibly representing a deeper understanding of the teachings of the Buddha. In practice, the literature served to distinguish one school from another, guarding against and/or [End Page 637]correcting the "erroneous" teachings of the other schools. Over a period of approximately three centuries, the Abhidhamma Pitaka grew rapidly…in terms of the sheer volume of literature as well as complexity of doctrine. Paralleling that increase, it came to play a position of ever greater prominence, rivaling even the canonical collections of the Buddha's word (the Sutta and Vinaya Pitakas). Together the three became known as the Tipitaka: "Three Baskets of the Doctrine."Unfortunately for scholars, the only Abhidhammas to survive the widespread persecution of Buddhism in India during the twelfth century A.D.were those that had been transported to, and transplanted in, other lands. Specifically, the Theravāda Abhidhamma (seven books in Pāli) found an enduring home in Sri Lanka. The Sarvāstivāda Abhidhamma (also seven books) along with the Śāriputra-abhidharmaśāstra(probably the Dharmaguptaka School) were carried to China, where they were translated from Sanskrit into Chinese. Of these, it is the Theravaāda collection— particularly its first book (the Dharmasanganī) as well as the seventh book (the Patthana)—that forms the subject matter of Ven. Nyanaponika's study. The other two schools have long since vanished, except, as Bhikkhu Bodhi points out, that "a late exposition of the Sarvāstivāda Abhidhamma system, Vasubandhu's Abhidharmakośa, continues to be studied among Tibetan Buddhists and in the Far East" (p. x).Abhidhamma Studiesis divided into five chapters and two appendixes. Chapter 1, which was added in the second edition, provides a brief historical overview of "The Abhidhamma Philosophy." Those who approach the Abhidhamma... (shrink)

Il Cuore della Meditazione Buddhista. Nyanaponika Thera, translated into Italian by Nazzareno Ilari. Ubaldini Editore, Rome 1978, 209 pp. Lire 6000.

A Treasury of the Buddha's Words: Discourses from the Middle Collection. Translated by Nanamoli Thera, edited and arranged by Phra Khantipalo. 3 vols, Mahamakut, Bangkok, but available only from Wat Buddha-Dhamma, Ten Mile Hollow, Wisemans Ferry, NSW 2255, Australia.

A Thinker's Note Book.. Published, edited and introduced by Ven. Nyanaponika, Forext Hermitage Kandy. 254pp.

This article first briefly examines the textual structure of the Vangisathera Samyutta of the Pali Samyutta-nikaya in conjunction with two other versions preserved in Chinese translation in Taisho vol. 2, nos. 99 and 100. Then it compares the main teachings contained in the three versions. These three versions of this collection on the subject of the venerable Vangisa represent three different early Buddhist schools within the Sthavira branch. This comparative study of these three different versions focuses on three major topics: (...) Arhants at the pravarana ceremony; sensual desire and the way to extinguish it; and the Buddha’s teachings to Vangisa. It reveals similarities and significant differences in structure and doctrinal content, thus advancing the historical/critical study of early Buddhist doctrine in this area. (shrink)

Au total 1367 documents avec une inscription en linéaire A sur les 1427 connus peuvent être datés selon le système d'Evans. Ils permettent d'établir avec certitude que cette écriture a été en usage en Crète du MM II au MR I B, avec peut-être un prolongement au MR II. En dehors de Crète, elle est attestée dans les Cyclades, à Kéa au MM III et au MR I B, à Milos au MR I et à Théra au MR I A (...) ; elle est connue à Cythère au MM IIΙ Β-MR I Aet elle a même gagné la Laconie sans qu'on puisse dire à quelle époque. (shrink)

According to the Satipaṭṭhāna Sutta, mindfulness of the body involves seeing the body in a threefold way: ajjhattaṃ, bahiddhā, and ajjhattabahiddhā. This article attempts to show how an investigation of bodily perception, following the approach adopted by the phenomenologist Maurice Merleau-Ponty, can serve as the basis for a philosophically grounded understanding of the Pāli words ajjhattaṃ and bahiddhā. The interpretation that emerges is the distinction between “right here” and “out there”: two mutually dependent, internally related domains that are experienced as (...) what Merleau-Ponty called the “chiasm” or the “intertwining.” This is different from the standard interpretations found in the Abhidhamma, the Pāli commentaries, the Visuddhimagga, and the instructions of most contemporary meditation teachers. It is hoped that the interpretation offered here can give some exposure to a movement within Theravāda Buddhism, initiated by Ñāṇavīra Thera but slowly gaining traction, characterized by a phenomenological reading of the Pāli sutta s. (shrink)

The Sārasaṅgaha is a Pāli text of XIIth–XIIIth century by the Sinhalese monk Siddhattha Thera. Its themes include the aspiration to become a Buddha, shrines, meditation, theories on rain, wind, gender and more. The main body consists of citations from the Nikāyas, the Jātakas, the Visuddhimagga and above all, from commentarial literature. By analysing the way the Sārasaṅgaha refers to and establishes a dialogue with the quoted works, this paper promotes a new assessment of the cultural and textual tendencies (...) that influenced the development of Buddhist literature especially in the Middle Ages. In particular, the analysis of this text and the quotations of which it is composed reveals the importance of commentarial literature, a literary genre that only recently has attracted the attention of Pāli scholars. (shrink)

Buddhism, now a 2,500-year-old religion, very quickly became associated with the study of texts, of which it contained a considerable number. During the development of Buddhism on the territory of Czechoslovakia, since the days of Austria-Hungary, there have been attempts to find, translate, or write a fundamental book of Buddhism, which would help one to orient oneself in the vast and varied material of Buddhist texts. However, none of the books achieved this significance. In 1914–1915, 1917, and 1925, Dharma – (...) Buddhist Catechism by Henry S. Olcott was published in three different editions with an introduction by O. Pertold. The book was very popular then but did not reach world fame. The situation changed after 1935 when Nyanatiloka’s The Word of the Buddha was published in Dvůr Králové nad Labem. After the Velvet Revolution, it was published several times by Mirko Frýba (Áyakusala Thera) in his translations (1993 with commentary by Květoslav Minařík, 1998, 2006, 2010, and 2013, it is republished with a commentary by Květoslav Minařík with a modified translation from 1935). The book was used by František Drtikol (known as the Patriarch of Czech or Czechoslovak Buddhism) and his disciples and future Buddhists (like Frýba) from 1936 to the present. Thanks to frequent copying and distribution during and after the period of communist unfreedom, as well as its connection to the Czechoslovak Buddhist tradition, this book became, at least for the linguistic region of Bohemia (Czech Republic) and Slovakia, the “fundamental book of Buddhism.” One of the primary sources for this article was the oral tradition handed down by Czech masters. (shrink)

This is a very good book. It gives 205 inscriptions from ten of the Cycladic islands. A number of them are published here for the first time. In their majority they are either funerary or invocations for divine help. Some are dedicatory. Some are inscriptions on well-paintings identifying the scene or the saint depicted or being themselves dedicatory or invocatory. Some are in praise of God or in thanks to God. Some are exhortations to the faithful or quotations from the (...) Scriptures. Two are boundary stones and two are magical exorcisms. Outstanding among them are the cadastre of the area of Perissa on the island of Thera, the invocations for divine help carved by weatherbeaten seafarers on the rocks of the desert cove of Grammata (= Letters) on the island of Syros, and the intriguing 60-odd funerary inscriptions of the angels, also from Thera, that keep defying explanation. As a whole they give an insight and lead to a close intimacy with the life of the islanders in these early centuries, fortified as they were by the christian faith, toiling on the thin soil of their land and venturing at sea. Some of them raise questions that cannot be easily answered. Others are quite straightforward. (shrink)

The Buddhist technical term was first translated as ‘mindfulness’ by T.W. Rhys Davids in 1881. Since then various authors, including Rhys Davids, have attempted definitions of what precisely is meant by mindfulness. Initially these were based on readings and interpretations of ancient Buddhist texts. Beginning in the 1950s some definitions of mindfulness became more informed by the actual practice of meditation. In particular, Nyanaponika's definition appears to have had significant influence on the definition of mindfulness adopted by those who (...) developed MBSR and MBCT. Turning to the various aspects of mindfulness brought out in traditional Theravāda definitions, several of those highlighted are not initially apparent in the definitions current in the context of MBSR and MBCT. Moreover, the MBSR and MBCT notion of mindfulness as ‘non-judgmental’ needs careful consideration from a traditional Buddhist perspective. Nevertheless, the difference in emphasis apparent in the theoretical definitions of mindfulness may not be so significant in the actual clinical application of mindfulness techniques. (shrink)

Više začuđuje da je Aristip, koji se smatra rodonačelnikom kirenskog hedonizma, sokratovac, nego činjenica da je rodom iz mediteranske Kirene. Grad u kome je rođen, osnovali su nekoliko stoljeća prije grčki koloni, koji su došli s otoka Tere. Po Pindaru, njegova je porodica bila najbogatija i najuzvišenijeg roda u cijeloj Libiji, čime se objašnjava činjenica što je budući hedonist, od malena, bio naviknut na život u raskoši. Nikada ga nisu smatrali sokratovcem u pravom smislu te riječi , što će biti (...) razlogom spora među Sokratovim sljedbenicima. Svijet čulne realnosti kojem je on pripadao, s jedne strane, te Platonov idealni, s druge, implicira pitanje Sokratova izvornog učenja: hedonistički, kirenski ili onaj platonizirani Sokrat, kako sugerira najveći broj istraživača?The fact that Aristippus, considered the founding father of Cyrenaic hedonism, is a Socratic is far more astounding than the fact that he was born in Cyrene on the Mediterranean. His hometown was founded a few centuries earlier by Greek colonists arriving from the Island of Thera. According to Pindar, his family was the richest and of the noblest lineage in the whole of Libya, which says that this future hedonist had been used to a life in luxury ever since he was born. He was never considered a Socratic in the true sense of the word , which was to become the cause of controversy between Socrates’s followers. The world of sensual reality he belonged to on the one hand and Plato’s world of ideas on the other pose the question of Socrates’s original orientation – was he originally a hedonist, a Cyrenaic or a Platonist, which is what most researchers suggest? (shrink)

La Semaine d'épigraphie créto-mycénienne a été organisée par l'École française d'Athènes du 24 au 28 mars 1998, dans le but de réunir, pour quelques séances de travail, des savants reconnus et de jeunes doctorants spécialisés dans l'étude des écritures linéaires A et B. Chacun des participants a présenté un état de ses recherches personnelles : M.-L. Bech Nosch, L'administration des textes en Crète centrale, hors des séries Lc/Le/Ln ; Chr. Boulotis, Les nouveaux documents en linéaire A d'Akrotiri (Théra) : remarques (...) préliminaires ; P. Carlier, wa-na-ka derechef. Nouvelles réflexions sur les royautés mycéniennes; P. Darcque, Archives réelles, archives virtuelles en linéaire B; H. Landenius Enegren, Some Problems of the Prosopography of Knossos; J. T. Killen, The Pylos Ta Tablets Revisited ; S. Lupack, The Role of the Religious Sector in Mycenaean Economics; J.-P. Olivier, Le syllabaire chyproclassique : un inventaire; M. Perna, Gli ideogrammi dei vasi in lineare A ; Fr. Rougemont, Quelques problèmes liés à l'étude des «collecteurs» dans les tablettes en linéaire B; M.-St. Speciale, Gli antroponimi in lineare B di Cnosso e la Creta del TM II-III; M. Tsipopoulou, The Hieroglyphic Archive at Petras, Siteia ; C. Varias Garcia, Antroponimia micénica en las tablillas de h sene B de Cnoso y en Micenas. (shrink)

Concept of ethics in Ādi-Granth, Sikh canon.

In this paper we examine the functional anatomy of volition, as revealed by modern brain imaging techniques, in conjunction with neuropsychological data derived from human and non-human primates using other methodologies. A number of brain regions contribute to the performance of consciously chosen, or ‘willed', actions. Of particular importance is dorsolateral prefrontal cortex , together with those brain regions with which it is connected, via cortico-subcortical and cortico-cortical circuits. That aspect of free will which is concerned with the voluntary selection (...) of one action rather than another critically depends upon the normal functioning of DLPFC and associated brain regions. Disease, or dysfunction, of these circuits may be associated with a variety of disorders of volition: Parkinson's disease, ‘utilization’ behaviour, ‘alien’ and ‘phantom’ limbs, and delusions of ‘alien control’ . Brain imaging has allowed us to gain some access to the pathophysiology of these conditions in living patients. At a philosophical level, the distinction between ‘intentions to act', and ‘intentions in action’ may prove particularly helpful when addressing these complex disturbances of human cognition and conscious experience. The exercise and experience of free will depends upon neural mechanisms located in prefrontal cortex and associated brain systems. (shrink)

Description from a book review by J. G. Beebe-Center: "Mr. Allen's book develops in detail the view that pleasure and unpleasure are essentially manifestations of the progression and thwarting of impulses. Part one is a brief summary of the principal theories of feeling. Part two is devoted to "sensory" or "bodily" pleasure and unpleasure. These forms of feeling, it is argued, 'depend on an analogue of conation existing in the organism, a nisus to maintain, or to carry out to the (...) full extent, the functioning proper to the bodily system.' Part three -- the piece de resistance (about half the book) -- deals with the relation of pleasure and unpleasure to the main instincts. Parts four, five and six take up a number of classical problems: the relation of pleasure and unpleasure to sensation, their relation to desire, the relativity of feelings, the qualitative variety of feelings, and the psychology of values. The author shows throughout a rare combination of historicophilosophical sophistication and of first-hand familiarity with the modern experimental literature.". (shrink)

What significance does the body have in the process of teaching and learning? In what way can the thoughts of a contemporary junior-level teacher in this regard be connected to the theory of the lived body formulated by the French phenomenologist philosopher Maurice Merleau-Ponty (1908-1961), and vice versa? The aim of this paper is to illuminate, enable understanding and discuss the meaning of the body in the learning process, with specific focus on the learning of writing as embodied experience. In (...) the process, the boundaries of learning are also explored. While understanding the significance both of learning as embodied experience and of the boundaries of learning is essential within the educational field, in this paper the discussion is limited to exploring how learning as embodied experience and the boundaries of learning can be viewed by taking Merleau-Ponty's notions as theoretical starting points. In an attempt to answer the aim and connect the paper's theoretical point of departure with a voice from a teacher, an interview with a junior-level teacher was conducted. The paper thus offers a theoretical contribution to the field of educational research, but one in which the theory is exemplified by, and connected to, a teacher's voice. Accordingly, the paper concludes by summarising the common understandings of learning held theoretically by Merleau-Ponty and made real in the activities of the contemporary junior-level teacher. (shrink)

Lectures based on the commentaries on Brahmasūtra of Bādarāyaṇa.

The relation between Church and state is nowadays at stake. This article concerns the relation between Church and state from an ecclesiastical and canonical point of view. It makes clear, how the ecclesiastical doctrine reacts to social developments in relation to the national state in order to safeguard the independence of the Church. The 19th century ecclesiastical doctrine on the Church as a societas perfecta reacts on doctrines on the national states, which claimed absolute sovereignty and by that subordinated the (...) Church to the civil government and civil law. With societas perfecta doctrine the Church defends its sovereignty in the domain of the spiritual good of men. In this way the Church defines and protects its divine origin and independence from the national state. In the first half of the 20th century the democratic and constitutional national states were developed, which acknowledges religious freedom on a constitutional level as a human and a civil right. Because of this progress the Second Vatican Council could formulate its doctrine on religious freedom based on the traditional ecclesiastical teaching of the freedom of the religious act. By then, the independence of the Church is founded and defended on the freedom of the Church, which is guaranteed in national states, which acknowledge religious freedom as a human and civil right. Although one can say that there is discontinuity in the ecclesiastical teaching on the Church as a societas perfecta and the ecclesiastical doctrine on religious freedom, there exists also continuity, because both ecclesiastical doctrines intend to safeguard the independence of the Church in human society. (shrink)

The Kalama-sutta is frequently cited as proof of the rational and empirical spirit of early Buddhist epistemology, ‘The Buddha’s charter of free enquiry’, according to Soma Thera. A close reading, however, calls that interpretation into question. The Kalamas do not ask what is the truth, and the Buddha does not tell them how to find it. Rather the Kalamas ask ‘Who is telling the truth?’ in what may have been the pursuit of sacred or quasi magical power through the (...) person of a teacher. The Buddha, in turn, encourages them to adopt a set of attitudes and actions, which includes choosing a teacher. The method of evaluation that the Buddha gives, which includes the famous ‘know for yourselves’ is found to be as least as much ethical as it is epistemological and to invoke the opinion of authority and the public. The Buddha here seems to call for a decision that is partly based on faith, and the Kalamas respond not with independent research, but with an act of faith in committing themselves to the Buddha. (shrink)

Background: Only data of published study results are available to the scientific community for further use such as informing future research and synthesis of available evidence. If study results are reported selectively, reporting bias and distortion of summarised estimates of effect or harm of treatments can occur. The publication and citation of results of clinical research conducted in Germany was studied.Methods: The protocols of clinical research projects submitted to the research ethics committee of the University of Freiburg in 2000 were (...) analysed. Published full articles in several databases were searched and investigators contacted. Data on study and publication characteristics were extracted from protocols and corresponding publications.Results: 299 study protocols were included. The most frequent study design was randomised controlled trial , followed by uncontrolled studies , laboratory studies and non-randomised studies . 182 were multicentre studies including 97 international collaborations. 152 of 299 had commercial funding and 46 non-commercial funding. 109 of the 225 completed protocols corresponded to at least one full publication ; the publication rate was 48%. 168 of 210 identified publications were cited in articles indexed in the ISI Web of Science. The median was 11 citations per publication .Conclusions: Results of German clinical research projects conducted are largely underreported. Barriers to successful publication need to be identified and appropriate measures taken. Close monitoring of projects until publication and adequate support provided to investigators may help remedy the prevailing underreporting of research. (shrink)

L’article esquisse d’abord le dispositif institutionnel d’accueil familial théra--peutique ( aft ) au sein duquel se déploie chez l’enfant la problématique étudiée – une affiliation spécifique en accueil familial. Il précise les conditions et les dynamiques de prise en charge en séparation protectrice, ici à dimension thérapeutique. Le cas clinique illustre l’évolution de l’affiliation, conforme à une longue expérience empirique acquise par l’équipe de professionnels dans l’accompagnent des dynamiques psychiques chez les enfants qui bénéficient de deux pôles d’affiliation, à travers (...) les liens avec la famille et la famille d’accueil. En appui sur les recherches et les articles parus sur ce sujet et sur les résultats d’une récente étude évoquant le destin des affiliations en accueil familial, l’auteur développe le concept de « double affiliation » que déploient les enfants en accueil familial dont le destin dépendra de la qualité du cadre d’accompagnement professionnel (humain et matériel) d’une telle situation existentielle extrême. (shrink)

1. Les îles de Kimolos, Pholegandros, Sikinos et Théra ont été intégrées dans l'empire athénien à la suite de l'expédition d'Alcidas (427), pour verrouiller la mer Egée. 2. Les diminutions du tribut de Colophon et Notion dans les années vingt sont à mettre en rapport avec les opérations de Pachès en 427 et la « nouvelle fondation » dont parle Thucydide (III, 34, 4). Appendice : II n'y a pas eu de bordereau de taxation en 428. La liste ATL II, (...) 27, qui date de 426/5, reflète le bordereau de la période VIII, qui n'a duré qu'un an. (shrink)

Heleno Saña aborda los interrogantes y arcanos de la condición humana en sus más diversas manifestaciones. Ofrece una vasta síntesis de lo que ha sido el Hombre desde sus orígenes hasta nuestros días. Esta perspectiva integral le permite a la vez explicar el desarrollo de la Humanidad y de la historia universal en su conjunto. La nueva obra de este reputado filósofo constituye una excelente guía no sólo para descifrar las profundidades y misterios del alma humana, sus conflictos y sus (...) dramas internos, sino también para superarlos. Quien se asome a las páginas de este libro estará en condiciones de conocerse a sí mismo y de dar a su vida el mayor sentido posible, a partir del sólido apoyo de la reflexión filosófica y antropológica. (shrink)